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By using this site you agree to the use of cookies in accordance with our cookie policy.OkThe shape and form of CLU gene expression in the perinatal period: a head start, a way of going and a departure to brain atrophy and Alzheimer’s disease.
The cerebral cortical development in normal humans follows a double gradient process: a presomitic center (center) and a rhombic lip (lip). Both features form a cap-like expansion of the lateral ventricles when the brain grows vertically, starting around 14 weeks of gestation. The center corresponds to the E14-E15 zone and belongs to the layer IV; the lip corresponds to E16-E17 and is localized in layer VI-V. In this study, we describe the localization and expression of the complement component C1q-like protein (CLU) protein in human brain development at mid gestation (12 to 20 weeks of gestation). Here we show that CLU has a dynamic pattern of expression at the scale of this developmental period. CLU is synthesized in the center and the lip, but its expression is preferentially localized in the lip. This is followed by a progressive decline of CLU during the late stages of gestation and after birth. CLU transcript is not abundant in prenatal cerebellar development, whereas its expression becomes abundant in the cerebellum in infancy. There is a decrease in CLU transcript and protein expression levels in the cortex of Alzheimer’s disease brains. On the basis of these observations, we propose the hypothesis that the premature disappearance of CLU may be responsible for the development of cortical atrophy in Alzheimer’s disease. This seems to be the first functional observation of a protein implicated in Alzheimer’s disease.Q:

Sorting dates

I have records in my database like this:
Record 1:
Date | ID
2014-02-27 | 1

Record 2:
Date | ID
2014-02-29 | 1

Record 3:
Date | ID
2014-02-23 | 1

Record 4:
Date | ID
2014-02-26 | 1

Record 5

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The Delta Antirrhinum is an extinct genus of ant in the formicid subfamily Formicinae. The genus is known from subfossil remains found in a phosphatic sandstone at the Holzmaden locality in Germany.

The Delta Antirrhinum is most similar to the extinct genera Camponotus, Conopomorpha, and Dolichomyrmex. In general outline, it differs from all three in having elongate tarsi, whereas the tarsi of Camponotus and Dolichomyrmex are about half the length of those of the Delta Antirrhinum.

References


Category:Eocene insects
Category:Fossil ant genera
Category:Fossil taxa of Europe
Category:Fossil insects of Europe
Category:Taxa named by Ignaz von Stampfer
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Easysnap SHP1000: exploring the strange land of the snap-in-place switch

Sony has been airing its new product, the Easysnap SHP1000, at trade shows for a while now. Made in Germany, the unit offers the first in-mould snap-in-place spring-loading mechanism and is branded ‘the first in the world’.

Although the patent was published earlier this year, the first pics have just gone public. So what do we know about this technology?

So far, it’s not that much, but we should start by looking at the technology. The first is that the manufacturer says this is a new electronic technology and not an acoustic one, as with conventional snap-in-place switches. It’s also said that this technology is not compatible with any other snap-in-place switch.

Sony says the unit is aimed at lower-priced yet high-quality D-input devices such as FM receivers, and TV sets.

An electro-mechanical device makes up the heart of the latest Easysnap technology. Simply put, the device is put in the mould and the mechanical assembly is completed automatically by a special mechanism.

The unit is designed to operate efficiently, offers a low-wear rate and is low in power consumption, thereby contributing to the product’s operating lifetime.

The unit was designed to meet a demand from a completely different market and to fill the gap, which exists in the industry today for single pole, 3-way and 4-way switches.

Size

The unit is 63.7mm

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